个人简介：史万玉，男，汉族，博士，二级教授，博士生导师，河北农业大学动物医学院/中兽医学院副院长；河北省农业产业技术体系创新团队中兽药岗位专家、河北农业大学太行学者、济南市泉城学者、河北农业大学中兽医学科带头人；国家兽药典委员、农业农村部新兽药评审专家、全国动物卫生标准化技术委员会委员；亚洲传统兽医与中兽医学会副理事长、中国畜牧兽医学会中兽医学分会副理事长、中国兽医协会中兽医分会副理事长、华北地区中兽医研究会秘书长、河北省畜牧兽医学会中兽医学分会会长。近年来，取得科研成果18项，其中获省级以上奖10项。在国际SCI期刊发表论文50多篇，核心期刊120多篇，出版著作10余部，以第一发明人获国家发明专利6项，获国家新兽药证书8个。目前主持的在研项目8项，其中，国家自然科学基金项目2项，国家十四五重点研发计划课题1项、河北省自然科学基金1项，河北省重点研发项目1项。曾先后赴台湾、韩国、日本、美国、加拿大、西班牙、德国、法国、荷兰、比利时等十多个国家和地区进行学术交流与业务考察。

电子邮箱：shiwanyu2010@126.com

通讯地址：保定市莲池区乐凯南大街2596号

研究方向：中药药理与中兽药现代化；畜禽疾病防治与新型中兽药创制

主讲课程：《中兽医学》、《中兽医基础理论》、《中兽医案例分析》、《中兽医诊疗技术》

一、科研获奖：

1.“新型中兽药的创制及其在鸡健康养殖中的技术集成与应用”2020年获河北省科技进步二等奖。

2．“奶牛主要疾病综合防控关键技术研究与应用”，2013年获河北省科技进步二等奖。

3.“黄芩等中药及成分对母胎界面的免疫调节作用”，2010年获河北省自然科学三等奖。

4.“促孕保胎中药防治母牛早期胚胎丢失的研究与应用”，2005年获河北省科技进步三等奖。

5.“中药黄藿超微粉提高蛋鸡生产性能与免疫力技术研究”，2007年获河北省科技进步三等奖。

6.“健脾中药对鸭胰液分泌的调节作用” 2007年获河北省科技进步三等奖

7.“华北农区奶牛主要疾病防治技术与产业化示范”，2007年获河北省科技进步三等奖。

8.“子宫自然杀伤细胞及相关细胞因子与母牛早期流产的相关性” 2003年获河北省自然科学三等奖。

9.黄芪茎叶超微粉提高蛋鸡免疫力和生产性能技术研究与应用（12150132A），2016年获石家庄市科技进步二等奖。

二、代表性论著：

[1] Bao Yongzhan, Jing Cui, Shi Wanyu. Effects of Chinese herbal recipes on immunity in immunosuppressive mice[J]. African journal of traditional, complementary, and alternative medicines : AJTCAM,2012,9(4):548-552. （医学四区，IF:0.707）

[2] Cheng Jingjing, Li Qingyan, Shi Wanyu, Zhong Xiuhui. Effects of Huangqi Maxingshigan decoction on infectious laryngotracheitis in chickens[J]. Italian Journal of Animal Science, 2011, 10 (2):124-130.（农林科学三区，IF:0.342）

[3] Yongzhan Bao, Wanyu Shi, Jianhua Qin. Effects of Chinese herbal formula "Kangshu I" on the blood heat shock protein (HSP70) and levels of some hormones in heat-stressed cows[J]. journal of medicinal plant research, 2011, 5(32):7061-7064.（医学四区，IF:0.879）

[4] Wang Xiaodan,Ma Aituan, Shi Wanyu, Geng Meiying, Zhong Xiuhui,Zhao Yantao. Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice[J]. Evidence-based complementary and alternative medicine: eCAM,2011,2011:745262.（医学三区，IF:4.774）

[5] Haifeng Hou, Qian Li, Wanyu Shi, Yongzhan Bao. Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens[J]. African Journal of Pharmacy & Pharmacology, 2012, 6(14):1037-1044. （医学四区，IF:0.839）

[6] Haifeng Hou,Yongzhan Bao,Qian Li,Wanyu Shi, ShiBing Su. Preparation of Blood-Deficient Model and Research of Angelica Polysaccharide on Enriching Blood in Chickens[J]. Evidence-Based Complementary and Alternative Medicine,2012,2012:965947. （医学三区，IF:1.772）

[7] Chunhong Li, Yulong Dong, Haifeng Hou, Qian Li, Ruihua Zhang, Ruiling Qin, Zhonghao Li, Yongzhan Bao, Wanyu Shi. Effects of traditional Chinese herbal medicines on blood cell count and immunity in chickens[J]. African journal of pharmacy and pharmacology, 2013, 7(29):2081-2086. （医学四区，IF:0.839）

[8] Chunhong Li, Wei Shi, Wanyu Shi. Mitochondrial genome sequence of Egyptian swift Rock Pigeon ( Columba livia breed Egyptian swift)[J]. Mitochondrial DNA,2014,26(3): 479-480.（生物三区，IF:1.6）

[9] Nan Xi, Jia Kang, Lijuan Hao, Ruijuan Li, Yongzhan Bao, Wanyu Shi. Effects of ultrafine powder of the stem and leaf of Astragalus on immunity in chickens[J]. Italian Journal of Animal Science, 2014, 13(1):3022.（农林科学三区，IF:0.718）

[10] Li Chunhong, Jin Shugang, Dong Yulong, Wang Li, Shi Wanyu. The complete mitochondrial genome of Rhodeus lighti (Cypriniformes: Cyprinidae): sequencing and analysis[J]. Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis,2016,27(3):2298-2299.（生物四区，IF:0.575）

[11] Chunhong Li,Yulong Dong,Zhong Hao Li,Ruihua Zhang,Ruiling Qin,Li Wang,Wanyu Shi. Effects of traditional Chinese herbal medicines on egg production, egg quality and antioxidant enzyme activities in aged laying hens[J]. Indian Journal of Animal Research,2017,51(2).（农林科学四区，IF:0.201）

[12] Shuang Ma, Wanyu Shi, Xiaodan Wang,Pengyan Song, Xiuhui Zhong. Bisphenol A Exposure during Pregnancy Alters the Mortality and Levels of Reproductive Hormones and Genes in Offspring Mice[J]. BioMed Research International,2017,2017:3585809.（医学三区，IF:2.583）

[13] Han Chao,Yang Jinkai,Song Pengyan,Wang Xiao,Shi Wanyu. Effects of Salvia miltiorrhiza Polysaccharides on Lipopolysaccharide-Induced Inflammatory Factor Release in RAW264.7 Cells[J]. Journal of interferon and cytokine research, 2018,38(1): 29-37.（医学三区，IF：2.419）

[14] Shuang Ma,Ruiwen Li,Xincheng Gong, Wanyu Shi, Xiuhui Zhong. Lycopene reduces in utero bisphenol A exposure-induced mortality, benefits hormones, and development of reproductive organs in offspring mice[J]. Environmental Science and Pollution Research,2018,25(24): 24041-24051. （环境科学与生态学三区，IF:2.8）

[15] Tie Zhang,Jian Chen,Chunguang Wang,Wanyu Shi, Dinggang Li. The therapeutic effect of Yinhuangerchen mixture on Avian infectious laryngotracheitis[J]. Poultry Science,2018,97(8):2690-2697.（农林科学二区TOP，IF:2.216）

[16] Wang Xiao,Han Chao,Qin Jiaojiao,Wei Yuanyuan,Qian Xufeng,Bao Yongzhan,Shi Wanyu. Pretreatment with Salvia miltiorrhiza Polysaccharides Protects from Lipopolysaccharides/d-Galactosamine-Induced Liver Injury in Mice Through Inhibiting TLR4/MyD88 Signaling Pathway[J]. Journal of interferon and cytokine research,2019, 39(8):495-505.（医学三区，IF:1.774）

[17] C.H. Li,Y.L. Dong,W.Y. Song,R.H. Zhang,J.L. Li,L. Wang, W.Y. Shi, T. Xu. Effects of traditional Chinese herbal medicines on blood parameters and antibody level in laying hens[J]. Indian Journal of Animal Research,2019,53(9):1194-1198.（农林科学四区，IF:0.437）

[18] Han Chao,Wei Yuanyuan,Wang Xiao,Ba Cuijing,Shi Wanyu*.Protective effect of Salvia miltiorrhiza polysaccharides on liver injury in chickens.[J]. Poultry science,2019,98(9): 3496–3503. （农林科学二区TOP，IF:2.027）

[19] Chao Han,Yuanyuan Wei,Xiao Wang,Yuqing Cui,Yongzhan Bao,Wanyu Shi*. Salvia miltiorrhiza polysaccharides protect against lipopolysaccharide-induced liver injury by regulating NF-κb and Nrf2 pathway in mice[J]. Food and Agricultural Immunology,2019,30(1): 979–994.（农林科学二区, IF:2.568）

[20] Yuanyuan Wei,Chao Han,Yumeng Geng,Yuqing Cui,Yongzhan Bao,Wanyu Shi*,Xiuhui Zhong. Maternal exposure to bisphenol A during pregnancy interferes testis development of F1 male mice[J]. Environmental Science and Pollution Research,2019, 26(23):23491-23504. （环境科学与生态学三区， IF:2.914）

[21] Shilei Zhang,Jialu Bao,Xincheng Gong,Wanyu Shi*, Xiuhui Zhong. Hazards of bisphenol A —— blocks RNA splicing leading to abnormal testicular development in offspring male mice[J]. Chemosphere,2019,230: 432-439. （环境科学与生态学二区TOP，IF:5.108）

[22] Yuanyuan Wei,Shuying Li,Chao Han,Yongzhan Bao,Wanyu Shi*. Cuscuta chinensis flavonoids alleviate bisphenol A‐induced apoptosis of testicular cells in male mice offspring[J]. Andrologia,2019,51(11): e13427.（医学四区，IF:1.84）

[23] Wei Yuanyuan,Han Chao,Li Shuying,Cui Yuqing,Bao Yongzhan, Shi Wanyu*. Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring.[J]. Food & function,2020,11(1):787-798.（农林科学一区TOP，IF:3.241）

[24] Yuanyuan Wei,Chao Han,Shuying Li,Yuqing Cui,Yongzhan Bao,Wanyu Shi*. Maternal exposure to bisphenol A during pregnancy interferes ovaries development of F1 female mice[J]. Theriogenology,2020,142:138-148.（农林科学二区TOP，IF:2.299）

[25] Chao Han,Yuanyuan Wei,Yuqing Cui,Yumemg Geng,Yongzhan Bao,Wanyu Shi*. Florfenicol induces oxidative stress and hepatocyte apoptosis in broilers via Nrf2 pathway[J]. Ecotoxicology and Environmental Safety,2020,191: 110239.（环境科学与生态学二区, IF:4.527）

[26] Chao Han, Yuanyuan Wei,Yumeng Geng,Yuqing Cui,Shuying Li,Yongzhan Bao,Wanyu Shi*. Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids[J]. Environmental Science and Pollution Research,2020, 27(25):31357-31368.（环境科学与生态学三区，IF:3.056）

[27] Chunhong Li, Yulong Dong, Ruihua Zhang, Li Wang, Wanyu Shi*, Tong Xu, Hongliang Zhang. Effects of Chinese Herbal Medicines on Lipid Metabolism and Immunity Function in Laying Hens[J]. Indian Journal of Animal Research, 2020, 54(10):1291-1295.（农林科学四区，IF:0.395）

[28] Wang Xiao,Han Chao,Cui Yuqing,Geng Yumeng,Wei Yuanyuan,Shi Wanyu*,Bao Yongzhan. Florfenicol induces renal toxicity in chicks by promoting oxidative stress and apoptosis[J]. Environmental science and pollution research, 2021, 28(1):936-946. （环境科学与生态学三区，IF:3.056）

[29] Xiao Wang,Chao Han,Yuqing Cui,Shuying Li,Guozhong Jin,Wanyu Shi*,Yongzhan Bao. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers[J]. Ecotoxicology and Environmental Safety,2021,207: 111282. （环境科学与生态学二区，IF:4.872）

[30] Cui YuQing,Han Chao,Li ShuYing,Geng YuMeng,Wei YuanYuan, Shi WanYu*,Bao YongZhan. High-throughput sequencing-based analysis of the intestinal microbiota of broiler chickens fed Compound Small Peptide of Chinese Medicine[J]. Poultry Science,2021, 100:100897.（农林科学二区TOP，IF:2.659）

[31] Han Chao, Wang Xiao, Zhang Di, Wei Yuanyuan, Cui Yuqing, Shi Wanyu*, Bao Yongzhan. Synergistic use of florfenicol and Salvia miltiorrhiza polysaccharide can enhance immune responses in broilers[J]. Ecotoxicology and Environmental Safety,2021,210:111825. （环境科学与生态学二区，IF:4.872）

[32]YumengGeng,ChunyuLu1,GuozhongJin,ShuyingLi,YuqingCui,ChaoHan,WanyuShi*,YongzhanBao Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol[J].. Environmental Science and Pollution Research, https://doi.org/10.1007 /s11356-021-15687-4, 13,August,2021（环境科学与生态学三区，IF:3.056）

[33]ChaoHan, YuqingCui, YiweiGuo, DiZhang, XiaoWang,YumengGeng, WanyuShi,* and Yongzhan Bao. Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injuy of broilers[J]. 2021 Poultry Science100:101228 https://doi.org/10.1016/j.psj.2021.101228.（农林科学二区TOP，IF:2.659）

[34] Chunyu Lu，Lu Zhang，Yuqing Cui，Guozhong Jin，Yongzhan Bao，Wanyu Shi*. Proteome and transcriptome explore the mechanism of Salvia miltiorrhiza polysaccharides to relieve forfenicol‑induced kidney injury in broilers Environmental Science and Pollution Research, https://doi.org/10.1007/s11356-022-19114-0,12, February,2022（环境科学与生态学三区，IF:3.056）

[35] Xiao Wang , Wei Liu , Guozhong Jin, Zhanjun Wu , Di Zhang , Yongzhan Bao, Wanyu Shi* Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis Ecotoxicology and Environmental Safety. 233 (2022) 113339 （环境科学与生态学二区，IF:5.23）

[36] Wei Liu , Xiao Wang ,Ying Liu , Siyuan Fang , Zhanjun Wu , Chao Han , Wanyu Shi* ,Yongzhan Bao. Effects of early florfenicol exposure on glutathione signaling pathway and PPAR signaling pathway in chick liver. Ecotoxicology and Environmental Safety. 237 (2022) 113529（环境科学与生态学二区，IF:5.23）

[37]Wei Liu , Ying Liu , Siyuan Fang , Weiyu Yao , Xiao Wang ,Yongzhan Bao , Wanyu Shi*. Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways[J]. Poultry Science (2022), doi: https://doi.org/10.1016/j.psj.2022.101989（农林科学二区TOP，IF:2.659）

[38]Cui Yuqing,Zhang Lu,Lu Chunyu,Dou Mengmeng,Jiao Yulan,Bao Yongzhan,Shi Wanyu*. Effects of compound small peptides of Chinese medicine on intestinal immunity and cecal intestinal flora in CTX immunosuppressed mice
[J]. Frontiers in Microbiology,2022,13.（生物学二区TOP）

[39] Zhang Di,Jin Guozhong,Liu Wei,Dou Mengmeng,Wang Xiao,Shi Wanyu*,Bao Yongzhan. Salvia miltiorrhiza polysaccharides ameliorates Staphylococcus aureus-induced mastitis in rats by inhibiting activation of the NF-κB and MAPK signaling pathways[J]. BMC Veterinary Research,2022,18(1).（农林科学二区）

[40] Xiao Wang , Wei Liu ,Ying Liu, Yulan Jiao , Chang Rong, Qi Liu, and Wanyu Shi*. Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway [J]. Poultry Science 101:102152 https://doi.org/10.1016/j.psj.2022.102152（农林科学二区TOP，IF:2.659）

[41] Xiao Wang, Wei Liu, Di Zhang, Yulan Jiao, Qianhui Zhao, Ying Liu,Wanyu Shi* ,Yongzhan Bao*. Salvia miltiorrhiza polysaccharides alleviate florfenicol-induced inflammation and oxidative stress in chick livers by regulating phagosome signaling pathway. Ecotoxicology and Environmental Safety. 249 (2023) 114428 (环境科学与生态学二区TOP，IF:5.23）

[42] Qianhui Zhao , Ying Liu , Xiao Wang , Yixuan Zhu, Yulan Jiao, Yongzhan Bao, Wanyu Shi*.Cuscuta chinensis ffavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring. Ecotoxicology and Environmental Safety. 255 (2023) 114831 (环境科学与生态学二区TOP，IF:5.23）

[43] Yuqing Cui , Lu Zhang , Ying Liu , Wei Liu , Wanyu Shi* and Yongzhan Bao*. Compound small peptide of Chinese medicine alleviates cyclophosphamide induced immunosuppression in mice by Th17/Treg and jejunum intestinal flora[J]. Frontiers in Microbiology,2023,1039287.（生物学二区TOP）

[44]《中兽医基础理论》（农业农村部“十四五”规划教材），中国农业出版社，2024（待出版），主编

[45]《兽医瘟病学》（农业农村部“十四五”规划教材），中国农业出版社，2024（待出版），主编

[46]《中兽医手册》（第三版）.中国农业出版社，2010，副主编。

[47]《中兽医学实验指导》（第三版），中国农业出版社，2016，5.副主编。

[48]《兽医中药学》，中国教育文化出版社，2006，7副主编

[49]《中兽医方剂学》中国教育文化出版社，2006，2副主编

三、专利与新兽药证书

[1]史万玉,包永占,梁思嘉,秦建华,曹立辉,李瑞娟,钟秀会,秦姣姣,梁银聚. 用于治疗猪支原体肺炎的中药组合物及其应用. 专利号：ZL201810139678.6.

[2]史万玉,曾勇庆,骆延波,陈宝江,吴传文,刘在青,肖建森,郭丽华,郑庆周. 一种母猪用复合中药营养添加剂及其制备方法. 专利号：ZL201510240712.5.

[3]史万玉,梁银聚,秦建华,邵欣华,曹立辉,甄盼盼,李彩虹,包永占,钟秀会,巴翠晶. 一种用于防治奶牛热应激的中药组方. 专利号：ZL201410694765.X.

[4]史万玉,罗永祥,康建南,钟秀会,黎明,文少怀,李林,康汇然,宋雪琴,胡智鹏. 一种治疗奶牛乳房炎的灌注剂制备工艺. 专利号：ZL201310223163.

[5]史万玉,罗永祥,康建南,武力,戈军珍,黎明,钟秀会. 提高肉禽免疫力和生产性能的中药口服液及其制备方法.专利号：ZL201210072257.9.

[6]史万玉,罗永祥,康建南,欧日风,黎美,黎明,李林. 一种治疗奶牛乳房炎的喷膜剂. 专利号：ZL201010294043.7.

[7]研发的国家三类新兽药“芪楂口服液”（2015新兽药证字19号），2015年4月获国家新兽药证书。

[8]研发的国家三类新兽药“黄藿口服液”（2016新兽药证字10号），2016年2月获国家新兽药证书。

[9]研发的国家四类新兽药“玉屏风颗粒”（2016新兽药证字17号），2016年3月获国家新兽药证书。

[10]研发的国家三类新兽药“柴黄口服液”（2019新兽药证字23号），2019年4月获国家新兽药证书。

[11]研发的国家三类新兽药“银黄二陈合剂”（2019新兽药证字22号），2019年4月获国家新兽药证书。

[12]研发的国家三类新兽药“金芩蓝口服液”（2020新兽药证字14号），2020年5月获国家新兽药证书。

[13]研发的国家三类新兽药“合欢磁牡口服液”（2021新兽药证字59号），2021年9月获国家新兽药证书。

[14]研发的国家三类新兽药“蒲虎颗粒”（2023新兽药证字22号），2023年4月获国家新兽药证书。

四、主要科研项目：