个人基本信息
何欣,博士,教授,博士生导师。主要研究方向为新兽药研发与残留控制。
电子信箱
hexinyangling22@163.com
通讯地址:河北省保定市乐凯南大街2596号河北农业大学西校区
教育/工作经历:
1999.9-2003.6 河北农业大学动物科技学院,动物医学学士
2003.9-2008.6 西北农林科技大学动物医学院,基础兽医学博士
2008.7至今 河北农业大学动物医学院 中兽医学院,教师
2015.3-2016.3 美国明尼苏达大学药学院,访问学者
科研项目:
1. 国家自然科学基金项目面上项目,基于“一药多靶”策略研究大豆苷元共晶缓解蛋鸡肝脏脂质代谢紊乱的作用机制,起止年月:2025.01-2028.12,50万元,主持。
2. 河北省自然科学基金重点项目,防治犊牛腹泻的高效缓释中药活性成分固体分散体的制备及作用机制研究,起止年月:2022.1-2024.12,50万,在研,主持。
3.国家自然科学基金项目青年基金项目,基于Caco-2/HT29-MTX细胞共培养体系的川芎嗪不同结构共晶吸收途径及机制研究,起止年月:2021.01-2023.12,24万元,结题,主持。
4.河北省重点研发计划项目,专项名称:农业高质量发展关键共性技术攻关专项,基于共沉淀的兽用抗菌药物固体分散体研究,起止年月:2020.01-2023.12,30万,结题,主持。
5.河北省高等学校科学技术研究重点项目,基于超分子的硝基咪唑类药物共晶设计、合成与性质研究,起止年月:2019.01-2021.12,5万,结题,主持。
6.国家自然科学基金项目,利用基于氢键的晶体工程设计中药共晶以改善其渗透性,起止年月:2019.01-2020.12,25万,结题,参研。
科研成果:
1. 纳米乳与微生物降解技术在畜禽健康养殖中的研究及应用,河北省科学技术进步三等奖,2014,排名第一。
2. 中药防治体系在山区生态养鸡中的研究与示范,河北省山区创业三等奖,2018,排名第二。
3. 畜禽疾病快速检测及中药防治体系的建立与应用,河北省科学技术进步三等奖,2020,排名第二。
4. 鸡重要传染病防控关键技术创新与应用,河北省科学技术进步二等奖,2018,排名第七。
发表论文:
1. Jianting Gao, Yingsai Fan, Chenyue Lu, Xinghua Zhao, Xin He*. The baicalein amorphous solid dispersion to enhance the dissolution and bioavailability and effects on growth performance, meat quality, antioxidant capacity and intestinal flora in Taihang chickens. Poultry Science. 2024, 103:103768. (JCR1区Top,IF=4.014)
2. Yanan Mao, Kairu Wang, Mengge Liu, Chenyue Lu, Xinghua Zhao, Xin He*. Enhancing the bioavailability of a novel enrofloxacin salt by inhibiting precipitation via a crystallization inhibitor. Crystal Growth & Design, 2024, 24: 2909-2917. (JCR2区,IF=4.089)
3. Xinghui Hao, Yuqing Zhang, Yanling Sun, Mengge Liu, Qiru Wang, Xinghua Zhao*, Xin He*. Polymorphs of a 1:1 salt of sulfadiazine and piperazine–relative stability, dissolution studies, pharmacokinetics and anti-meningitis efficiency. European Journal of Pharmaceutical Sciences.2023,188:106503. (JCR2区,IF=4.3)
4. Jia Cao, Shixia Zhang, Yanshuang Hao, Kai Fan, Lingling wang, Xinghua Zhao*, Xin He*. Amorphous solid dispersion preparation via coprecipitation improves the dissolution, oral bioavailability, and intestinal health enhancement properties of magnolol. Poultry Science. 2023, 102:102676. (JCR 1区Top,IF=4.014)
5. Kairu Wang, Yanshuang Hao, Chenguang Wang, Xinghua Zhao, Xin He*, Changquan Calvin Sun*. Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin and Ligustrazine through cocrystallization. International Journal of Pharmaceutics.2022, 616:121541. (JCR2区Top,IF=4.845)
6. Xinghui Hao, Jinhui Li, Chenguang Wang, Xinghua Zhao, Xin He*, Changquan Calvin Sun*. Profoundly improved photostability of dimetronidazole by cocrystallization. CrystEngComm.2022, 24:6165-6171. (JCR3区,IF=3.756)
7. Jin-Hui Li, Xing-Hui Hao, Chen-Guang Wang, Hai-Yan Liu, Lian-Chao Liu, Xin He* and Changquan Calvin Sun*. Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate.[J] Pharmaceutics 2021, 13(4), 546. (JCR2区,IF=4.313)
8. Xinghua Zhao#, Qiang Li#, Chenguang Wang, Xin He*, Changquan Calvin Sun*, Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet salts. International Journal of Pharmaceutics. 2020,577(3):119089. (JCR2区,IF=4.845)
9. Shenye Hu#, Chenguang Wang#, Xin He, Changquan Calvin Sun*. Correction to Reducing the Sublimation Tendency of Ligustrazine through Salt Formation. Crystal Growth & Design, 2020, 20: 2057-2063. (JCR2区,IF=4.089)
10. Bingjie Jia#, Xin He#, Penglei Cui,Juxiang Liu, Jianping Wang*. Detection of chloramphenicol in meat with a chemiluminescence resonance energy transfer platform based on molecularly imprinted graphene. Analytica Chimica Acta, 2019, 1063:136-143. (JCR2区,IF=5.977)
11. He X.#, Duan C.F.#, Qi Y.H., Dong J., Wang G.N., Zhao G.X., Wang JP, Liu J.*. Virtual mutation and directional evolution of anti-amoxicillin ScFv antibody for immunoassay of penicillins in milk. Analytical Biochemistry, 2017, 517:9-17. (JCR3区,IF=2.877)
12. He X.#, Wang G.N.#, Yang K., Liu H.Z., Wu X.J., Wang J.P.*. Magnetic graphene dispersive solid phase extraction combining high performance liquid chromatography for determination of fluoroquinolones in foods. Food Chemistry, 2017, 221:1226-1231. (JCR2区,IF=6.306)
13. 刘连超, 王灵灵, 张雨晴等. 反溶剂共沉淀技术制备氟苯尼考固体分散体. 畜牧兽医学报,2021,52(10):2934-2943.